Inconsistent effectiveness of myocardial preservation among cardiac chambers during hypothermic cardioplegia
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چکیده
منابع مشابه
Myocardial Preservation during Hypothermic Cardiopulmonary Bypass: A Team Endeavor
____________ _ Myocardial failure is the primary cause of death following operation using hypothermic cardiopulmonary bypass. The mean mortality rate for coronary bypass in Medicare patients in the United States for 1984 was 5.5%.1njury to the heart is caused by aortic cross-clamping or total circulatory arrest. The lesion of hypoxia is characterized by progressive acidosis. The severity of aci...
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Preservation of myocardial high-energy phosphates correlates with the heart's ability to resume normal function following aortic crossclamping (AXC). The ability of the canine myocardium to synthesize and maintain ATP during 180 minutes of AXC was evaluated in 12 hearts subjected to either blood or crystalloid cardioplegic arrest. Group 1 hearts were arrested by infusion of 750 ml of blood pota...
متن کاملMaintenance of aerobic metabolism during global ischemia with perfluorocarbon cardioplegia improves myocardial preservation.
We used phosphorus-31 nuclear magnetic resonance to test the ability of a perfluorocarbon blood substitute that has been shown in previous studies to improve oxygen delivery to hypothermic myocardium to maintain aerobic high-energy phosphate metabolism during total global ischemia. Twenty-three isolated perfused rabbit hearts were subjected to 180 min of hypothermic (23 degrees C) global ischem...
متن کاملAntioxidant Tempol enhances hypothermic cerebral preservation during prolonged cardiac arrest in dogs.
The authors are systematically exploring pharmacologic preservation for temporarily unresuscitable exsanguination cardiac arrest in dogs. They hypothesized that the antioxidant Tempol improves cerebral outcome when added to aortic saline flush at the start of cardiac arrest. In study A, no drug (n = 8), Tempol 150 mg/kg (n = 4), or Tempol 300 mg/kg (n = 4) was added to 25 mL/kg saline flush at ...
متن کاملMyocardial metabolism after hypothermic retrograde continuous blood cardioplegia with anterograde warm cardioplegic induction
Method: A metabolic analysis of hypothermic retrograde continuous blood cardioplegia with antegrade warm cardioplegic induction was performed in a prospective study of 15 patients scheduled for elective coronary artery bypass grafting. Arterial and coronary sinus blood samples were simultaneously taken: before establishing cardiopulmonary bypass, after anterograde warm cardioplegic induction, w...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1991
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(19)36857-6